Answer
Oct 08, 2026 - 10:18 AM
Silenor may interact with cimetidine, SSRIs (selective serotonin reuptake inhibitors) like sertraline, alcohol, central nervous system (CNS) depressants, antihistamines such as diphenhydramine, tolazamide, and MAOIs (monoamine oxidase inhibitors) such as phenelzine, tranylcypromine, methylene blue, and selegiline. Drug interactions can increase side effects or reduce effectiveness, so always inform your doctor about all medicines and supplements you are taking.
