Answer
May 06, 2026 - 11:09 AM
The boxed warning includes increased risks of cardiovascular disorders, breast cancer, endometrial cancer, and probable dementia. Estrogen plus progestin should not be used to prevent dementia or cardiovascular disease. The Women’s Health Initiative (WHI) study found higher risks of pulmonary embolism (PE), deep vein thrombosis (DVT), myocardial infarction (MI), and endometrial cancer, especially in postmenopausal women. Understanding boxed warnings helps you weigh the risks and benefits with your healthcare provider.
