Answer
Dec 10, 2025 - 09:33 AM
Medications and substances that may interact with Eliquis include over-the-counter aspirin, other aspirin-containing products, prolonged use of NSAIDs (nonsteroidal anti-inflammatory drugs like naproxen and ibuprofen), SSRIs (selective serotonin reuptake inhibitors), SNRIs (serotonin-norepinephrine reuptake inhibitors), other anticoagulants (warfarin, enoxaparin, heparin, platelet inhibitors), strong dual inhibitors of CYP3A4 and P-gp (such as ketoconazole, itraconazole, ritonavir, clarithromycin), strong inducers of CYP3A4 and P-gp (such as rifampin, carbamazepine, phenytoin, St. John’s wort), and grapefruit or grapefruit juice. Being aware of drug and food interactions prevents dangerous increases or decreases in medication effectiveness.
